5 grams containing approximately.5 mg of metronidazole) intravaginally once or twice a day for 5 days. Warnings If significant irritation develops from the use of this medication, discontinue use and consult your physician. 4 more Other Formulations Related treatment guides. A total of 46 drugs (396 brand and generic names) are known to interact with clindamycin. Store at room temperature. Care of the applicator If physician prescribes twice-a-day dosing: After use, pull the plunger out of the barrel. Chemically, metronidazole is a It has a chemical formula of C6H9N3O3, a molecular weight of 171.16, and has the following structure: metrogel-vaginal is a gelled, purified water solution, containing metronidazole at a concentration.5 mg/g (0.75). San Antonio, TX 78215 back panel: MetroGel-Vaginal(metronidazole vaginal gel).75 Vaginal Gel with 5 applicators Each gram contains:.5 mg of metronidazole,0.8 mg of methyl paraben, and.2 mg of propylparaben in a gel consisting of purified water, propylene glycol, carbomer 934P, and edetatedisodium. Plunger will stop when the applicator is full. Disulfiram-like reaction to alcohol has been reported with oral metronidazole, thus the possibility of such a reaction occurring while on metronidazole vaginal gel therapy cannot be excluded. Other: Unspecified cramping (1 Fatigue, Darkened urine.
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This results in the accumulation of metronidazole and its metabolites in the plasma. Pediatric Use: Safety and effectiveness in children have not been established. This is approximately 2 of the mean maximum serum metronidazole concentration reported in the same subjects administered a single, oral 500 mg dose of metronidazole (mean Cmax 12,785 ng/mL, range: 10,013 to 17,400 ng/mL). These peak concentrations were obtained in 6 to 12 hours after dosing with metronidazole vaginal gel and 1 to 3 hours after dosing with oral metronidazole. Two lifetime tumorigenicity studies in hamsters have been performed and reported to be negative. Important: The opening of this tube is covered by a metal tamper-resistant seal. How is MetroGel Vaginal Supplied metrogel-vaginal (metronidazole vaginal gel).75 Vaginal Gel is supplied in a 70 gram tube and packaged with 5 vaginal applicators. Psychotic Reactions: Psychotic reactions have been reported in alcoholic patients who were using oral metronidazole and disulfiram concurrently.
This has been observed in all six reported studies in that species, including one study in which the animals were dosed on an intermittent schedule (administration during every fourth week only). Usually avoid combinations; use it only under special circumstances. Minor, minimally clinically significant.